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Past its pain-relieving results, conolidine has demonstrated a good security margin in preclinical toxicology assessments. Contrary to opioids, which often result in respiratory melancholy at better doses, conolidine hasn't created indications of major respiratory suppression. Also, behavioral assessments in murine types propose an absence of drug-… Read More
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Most lately, it has been determined that conolidine and the above mentioned derivatives act around the atypical chemokine receptor three (ACKR3. Expressed in related areas as classical opioid receptors, it binds into a big range of endogenous opioids. Not like most opioid receptors, this receptor acts for a scavenger and doesn't activate a second m… Read More
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